2025 Toyota Sequoia Mpg. The epa rates a 4×2 sequoia to return 21 mpg in the city and 24 mpg on the highway, with a combined rating of 22 mpg. Use our handy tool to get estimated annual fuel costs based on your driving habits.
Smaller and refined v8s are also available. Epa mpg owner mpg estimates 2025 toyota sequoia 2wd 6 cyl, 3.4 l, automatic (s10) regular gasoline